Atrazine exposure decreases the activity of DNMTs, global DNA methylation levels, and dnmt expression
نویسندگان
چکیده
منابع مشابه
DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge
Chromatin can adopt a decondensed state linked to gene transcription (euchromatin) and a condensed state linked to transcriptional repression (heterochromatin). These states are controlled by epigenetic modulators that are active on either the DNA or the histones and are tightly associated to each other. Methylation of both DNA and histones is involved in either the activation or silencing of g...
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Epigenetic changes play an essential role in cancer pathogenesis. It has been established by next-generation sequencing that more than 50% of the human cancers carry mutations in mechanisms involved in the organization of the chromatin and epigenetic regulations. DNA methylation is among the most common epigenetic changes in leukemia. In contrast to DNA mutations which are passively inherited f...
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ژورنال
عنوان ژورنال: Food and Chemical Toxicology
سال: 2017
ISSN: 0278-6915
DOI: 10.1016/j.fct.2017.08.041